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Not the greatest game, really, but nicely original.
youtube,game,click,annotations YouTube's first-ever interactive game
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Not really useful as this kind of fast paced game, but more as a way of changing the storyline of a video clip. Interactive stories, like the books that where cool a couple of decades ago where it would say "If you want the kid to be eaten by the dragon continue to page 21, else continue on the next page."