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Quite informative
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It's a lecture by Craig C. Mello, who won the Nobel in 2006 for the discovery of RNA interference. He's a pretty good speaker. Of course it doesn't hurt that this is one of the most promising areas of medicine.
Return to the RNAi World: Rethinking Gene Expression and Evolution - Google Tech Talks April 9, 2007
http://video.google.com/videoplay?docid=-7104884525024111858&q=rnai&hl=en